Target of Rapamycin

Target of Rapamycin

How was it discovered? Rapamycin was discovered on Easter Island in a natural product screen for anti-fungicides and is produced by the soil bacteria, Streptomyces hygroscopicus. The Target of Rapamycin (TOR) was found in the yeast, Saccharomyces cerevisae, in a screen for mutants resistant to the cytostatic effects of the anti-mycotic. Two isoforms of the yeast protein were identified, TOR1 an...

Mechanistic Target of Rapamycin Inhibition

Mechanistic Target of Rapamycin Complex

Mammalian target of rapamycin inhibition.

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that has been increasingly recognized as key to the regulation of cell growth and proliferation. mTOR either directly or indirectly regulates translation initiation, actin organization, tRNA synthesis, ribosome biogenesis, and many other key cell maintenance functions, including protein degradation and transcription functions...

Regulating Mammalian Target of Rapamycin